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Nucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur

Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleo...

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Dades bibliogràfiques
Publicat a:Beilstein J Org Chem
Autor principal: Lönnberg, Tuomas
Format: Artigo
Idioma:Inglês
Publicat: Beilstein-Institut 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902050/
https://ncbi.nlm.nih.gov/pubmed/27340459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.12.67
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