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Single Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme

Proteolytic degradation of the extracellular matrix (ECM) is critical in cancer invasion, and recent work suggests that heterogeneous cancer populations cooperate in this process. Despite the importance of cell heterogeneity, conventional proteolytic assays measure average activity, requiring thousa...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Chen, Yu-Chih, Cheng, Yu-Heng, Ingram, Patrick, Yoon, Euisik
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901291/
https://ncbi.nlm.nih.gov/pubmed/27283981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27154
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