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Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese
We investigated the influence of gut microbiotal metabolism on the pharmacokinetics of berberine in healthy male Africans and Chinese. The C(max) and AUC in the Africans were 2.67-fold and 2.0-fold higher than the Chinese, respectively. Microbiotal compositions by 16S rRNA pyrosequencing showed high...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4901288/ https://ncbi.nlm.nih.gov/pubmed/27283523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27671 |
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