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Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese

We investigated the influence of gut microbiotal metabolism on the pharmacokinetics of berberine in healthy male Africans and Chinese. The C(max) and AUC in the Africans were 2.67-fold and 2.0-fold higher than the Chinese, respectively. Microbiotal compositions by 16S rRNA pyrosequencing showed high...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Alolga, Raphael N., Fan, Yong, Chen, Zhuo, Liu, Li-Wei, Zhao, Yi-Jing, Li, Jin, Chen, Yan, Lai, Mao-De, Li, Ping, Qi, Lian-Wen
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901288/
https://ncbi.nlm.nih.gov/pubmed/27283523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27671
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