Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk

AIMS/HYPOTHESIS: The pancreatic ATP-sensitive potassium (K(ATP)) channel plays a pivotal role in linking beta cell metabolism to insulin secretion. Mutations in K(ATP) channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, res...

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Detaylı Bibliyografya
Yayımlandı:Diabetologia
Asıl Yazarlar: Vedovato, Natascia, Cliff, Edward, Proks, Peter, Poovazhagi, Varadarajan, Flanagan, Sarah E., Ellard, Sian, Hattersley, Andrew T., Ashcroft, Frances M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901145/
https://ncbi.nlm.nih.gov/pubmed/27118464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3964-x
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