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High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine

Approximately 15 % of colorectal carcinomas (CRC) display high level microsatellite instability (MSI-H) due to either a germline mutation in one of the genes responsible for DNA mismatch repair (Lynch syndrome, 3 %) or somatic inactivation of the same pathway, most commonly through hypermethylation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Fam Cancer
Egile Nagusiak: Gatalica, Zoran, Vranic, Semir, Xiu, Joanne, Swensen, Jeffrey, Reddy, Sandeep
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Netherlands 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901118/
https://ncbi.nlm.nih.gov/pubmed/26875156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-016-9884-6
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