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Contextual Role of a Salt Bridge in the Phage P22 Coat Protein I-Domain

The I-domain is a genetic insertion in the phage P22 coat protein that chaperones its folding and stability. Of 11 acidic residues in the I-domain, seven participate in stabilizing electrostatic interactions with basic residues across elements of secondary structure, fastening the β-barrel fold. A h...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Harprecht, Christina, Okifo, Oghenefejiro, Robbins, Kevin J., Motwani, Tina, Alexandrescu, Andrei T., Teschke, Carolyn M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900280/
https://ncbi.nlm.nih.gov/pubmed/27006399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716910
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