Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions

The AHR is a ligand-activated transcription factor that mediates gene-environment interactions. Genome-wide expression profiling during differentiation of mouse ES cells into cardiomyocytes showed that AHR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin; Dioxin (TCDD), its prototypical ligand, dis...

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Dettagli Bibliografici
Pubblicato in:Toxicol Sci
Autori principali: Wang, Qin, Kurita, Hisaka, Carreira, Vinicius, Ko, Chia-I, Fan, Yunxia, Zhang, Xiang, Biesiada, Jacek, Medvedovic, Mario, Puga, Alvaro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
TCDD Disrupts Stem Cell and Cardiomyocyte Function
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900218/
https://ncbi.nlm.nih.gov/pubmed/26572662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv246
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