Moving Toward Integrating Gene Expression Profiling Into High-Throughput Testing: A Gene Expression Biomarker Accurately Predicts Estrogen Receptor α Modulation in a Microarray Compendium

Microarray profiling of chemical-induced effects is being increasingly used in medium- and high-throughput formats. Computational methods are described here to identify molecular targets from whole-genome microarray data using as an example the estrogen receptor α (ERα), often modulated by potential...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Ryan, Natalia, Chorley, Brian, Tice, Raymond R., Judson, Richard, Corton, J. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Integration of Microarray and High Throughput Toxicity Testing for Estrogen Receptor Function
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900138/
https://ncbi.nlm.nih.gov/pubmed/26865669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw026
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