Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity

Receptor-binding and subsequent signal-activation of interleukin-1 beta (IL-1β) are essential to immune and proinflammatory responses. We mutated 12 residues to identify sites important for biological activity and/or receptor binding. Four of these mutants with mutations in loop 9 (T117A, E118K, E11...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Wen-Ting, Huang, Wen-Yang, Chen, Ting, Salawu, Emmanuel Oluwatobi, Wang, Dongli, Lee, Yi-Zong, Chang, Yuan-Yu, Yang, Lee-Wei, Sue, Shih-Che, Wang, Xinquan, Yin, Hsien-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899739/
https://ncbi.nlm.nih.gov/pubmed/27278931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27729
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