Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Molecules of mitochondrial cardiolipin (CL) get selectively oxidized upon oxidative stress, which triggers the intrinsic apoptotic pathway. In a chemical model most closely resembling the mitochondrial membrane—liposomes of pure bovine heart CL—we compared ubiquinol-10, ubiquinol-6, and alpha-tocoph...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Lokhmatikov, Alexey V., Voskoboynikova, Natalia, Cherepanov, Dmitry A., Skulachev, Maxim V., Steinhoff, Heinz-Jürgen, Skulachev, Vladimir P., Mulkidjanian, Armen Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899610/
https://ncbi.nlm.nih.gov/pubmed/27313834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/8679469
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