Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles

BACKGROUND: It is difficult to discriminate healthy subjects and patients with Parkinson disease (PD) or Parkinson disease dementia (PDD) by assaying plasma α-synuclein because the concentrations of circulating α-synuclein in the blood are almost the same as the low-detection limit using current imm...

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Udgivet i:J Nanobiotechnology
Main Authors: Yang, Shieh-Yueh, Chiu, Ming-Jang, Lin, Chin-Hsien, Horng, Herng-Er, Yang, Che-Chuan, Chieh, Jen-Jie, Chen, Hsin-Hsien, Liu, Bing-Hsien
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898388/
https://ncbi.nlm.nih.gov/pubmed/27278241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-016-0198-5
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