HDAC Inhibition Impedes Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer

PI3K/AKT and RAS/MAPK pathway co-activation in the prostate epithelium promotes both epithelial-mesenchymal transition (EMT) and metastatic castration-resistant prostate cancer (mCRPC), which is currently incurable. To study the dynamic regulation of the EMT process, we developed novel genetically-d...

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Bibliografski detalji
Izdano u:Oncogene
Glavni autori: Ruscetti, Marcus, Dadashian, Eman L., Guo, Weilong, Quach, Bill, Mulholland, David J., Park, Juw Won, Tran, Linh M., Kobayashi, Naoko, Bianchi-Frias, Daniella, Xing, Yi, Nelson, Peter S., Wu, Hong
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896852/
https://ncbi.nlm.nih.gov/pubmed/26640144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.444
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