Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data

Technical variation plays an important role in microarray-based gene expression studies, and batch effects explain a large proportion of this noise. It is therefore mandatory to eliminate technical variation while maintaining biological variability. Several strategies have been proposed for the remo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Müller, Christian, Schillert, Arne, Röthemeier, Caroline, Trégouët, David-Alexandre, Proust, Carole, Binder, Harald, Pfeiffer, Norbert, Beutel, Manfred, Lackner, Karl J., Schnabel, Renate B., Tiret, Laurence, Wild, Philipp S., Blankenberg, Stefan, Zeller, Tanja, Ziegler, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896498/
https://ncbi.nlm.nih.gov/pubmed/27272489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156594
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