The Philadelphia chromosome in leukemogenesis

The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stabilit...

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Bibliographic Details
Published in:Chin J Cancer
Main Authors: Kang, Zhi-Jie, Liu, Yu-Fei, Xu, Ling-Zhi, Long, Zi-Jie, Huang, Dan, Yang, Ya, Liu, Bing, Feng, Jiu-Xing, Pan, Yu-Jia, Yan, Jin-Song, Liu, Quentin
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896164/
https://ncbi.nlm.nih.gov/pubmed/27233483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40880-016-0108-0
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