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The Philadelphia chromosome in leukemogenesis
The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stabilit...
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| 發表在: | Chin J Cancer |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4896164/ https://ncbi.nlm.nih.gov/pubmed/27233483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40880-016-0108-0 |
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