Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases

The vitamin D receptor (VDR) is a ligand-activated transcription factor that regulates gene expression in many cell types, including immune cells. It requires binding of 1,25 dihydroxy vitamin D(3) (1,25D3) for activation. Many autoimmune diseases show latitude-dependent prevalence and/or associatio...

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Detalhes bibliográficos
Publicado no:Genes Immun
Main Authors: Booth, D R, Ding, N, Parnell, G P, Shahijanian, F, Coulter, S, Schibeci, S D, Atkins, A R, Stewart, G J, Evans, R M, Downes, M, Liddle, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895389/
https://ncbi.nlm.nih.gov/pubmed/26986782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2016.12
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