The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

Tumour necrosis factor receptor-associated factor 6 (TRAF6) is a ubiquitin E3 ligase that regulates important biological processes. However, the role of TRAF6 in cardiac hypertrophy remains unknown. Here, we show that TRAF6 levels are increased in human and murine hypertrophied hearts, which is regu...

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Udgivet i:Nat Commun
Main Authors: Ji, Yan-Xiao, Zhang, Peng, Zhang, Xiao-Jing, Zhao, Yi-Chao, Deng, Ke-Qiong, Jiang, Xi, Wang, Pi-Xiao, Huang, Zan, Li, Hongliang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895385/
https://ncbi.nlm.nih.gov/pubmed/27249171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11267
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