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Store-independent modulation of Ca(2+) entry through Orai by Septin 7

Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a ‘molecular brake’ on activation of Orai channels in Drosophila neurons. Lowering Se...

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Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Deb, Bipan Kumar, Pathak, Trayambak, Hasan, Gaiti
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894974/
https://ncbi.nlm.nih.gov/pubmed/27225060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11751
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