An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression

OBJECTIVE—: The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous studies have identified 2 Flk1 regulatory enhancer...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Becker, Philipp W., Sacilotto, Natalia, Nornes, Svanhild, Neal, Alice, Thomas, Max O., Liu, Ke, Preece, Chris, Ratnayaka, Indrika, Davies, Benjamin, Bou-Gharios, George, De Val, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894770/
https://ncbi.nlm.nih.gov/pubmed/27079877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307517
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