The relative contribution of intramyocellular lipid to whole body fat oxidation is reduced with age, but subsarcolemmal lipid accumulation and insulin resistance are only associated with overweight individuals

Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both are associated with increasing age. It remains to be determined to what extent perturbations in IMCL metabolism are related to the ageing process per se. On two separate occasions whole-body and muscle insu...

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Veröffentlicht in:Diabetes
Hauptverfasser: Chee, Carolyn, Shannon, Chris E., Burns, Aisling, Selby, Anna L., Wilkinson, Daniel, Smith, Kenneth, Greenhaff, Paul L., Stephens, Francis B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894456/
https://ncbi.nlm.nih.gov/pubmed/26740597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1383
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