Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding

B-cell repertoire analysis using next-generation sequencing has become a valuable tool for interrogating the genetic record of humoral response to infection. However, key obstacles such as low throughput, short read length, high error rate, and undetermined bias of multiplex PCR method have hindered...

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Vydáno v:Sci Rep
Hlavní autoři: He, Linling, Sok, Devin, Azadnia, Parisa, Hsueh, Jessica, Landais, Elise, Simek, Melissa, Koff, Wayne C., Poignard, Pascal, Burton, Dennis R., Zhu, Jiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894419/
https://ncbi.nlm.nih.gov/pubmed/25345460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06778
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