E-cadherin-mediated force transduction signals regulate global cell mechanics

This report elucidates an E-cadherin-based force-transduction pathway that triggers changes in cell mechanics through a mechanism requiring epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase (PI3K), and the downstream formation of new integrin adhesions. This mechanism operates in ad...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Muhamed, Ismaeel, Wu, Jun, Sehgal, Poonam, Kong, Xinyu, Tajik, Arash, Wang, Ning, Leckband, Deborah E.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893802/
https://ncbi.nlm.nih.gov/pubmed/26966187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.185447
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