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Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development

All the major components of the WNT signalling pathway are expressed in female germ cells and embryos. However, their functional relevance in oocyte biology is currently unclear. We examined ovaries collected from TCFGFP mice, a well-known Wnt reporter mouse model, and found dynamic changes in the W...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kumar, Manish, Camlin, Nicole J., Holt, Janet E., Teixeira, Jose M., McLaughlin, Eileen A., Tanwar, Pradeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893675/
https://ncbi.nlm.nih.gov/pubmed/27265527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27273
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