Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9

Differential vulnerability among motor neuron (MN) subtypes is a fundamental feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) MNs are more vulnerable than fast fatigue-resistant (FR) or slow (S) MNs. The reason for this selective vulnerability remains enigmatic. We report here tha...

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Published in:Sci Rep
Main Authors: Morisaki, Yuta, Niikura, Mamiko, Watanabe, Mizuho, Onishi, Kosuke, Tanabe, Shogo, Moriwaki, Yasuhiro, Okuda, Takashi, Ohara, Shinji, Murayama, Shigeo, Takao, Masaki, Uchida, Sae, Yamanaka, Koji, Misawa, Hidemi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893611/
https://ncbi.nlm.nih.gov/pubmed/27264390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27354
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