Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques

OBJECTIVES: To explore the effects of tofacitinib—an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA)—with or without methotrexate (MTX), on MRI endpoints in MTX-naive adult patients with early active RA and synovitis in an index wrist or hand. METHODS: In this exploratory,...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Conaghan, Philip G, Østergaard, Mikkel, Bowes, Michael A, Wu, Chunying, Fuerst, Thomas, van der Heijde, Désirée, Irazoque-Palazuelos, Fedra, Soto-Raices, Oscar, Hrycaj, Pawel, Xie, Zhiyong, Zhang, Richard, Wyman, Bradley T, Bradley, John D, Soma, Koshika, Wilkinson, Bethanie
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Clinical and Epidemiological Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893111/
https://ncbi.nlm.nih.gov/pubmed/27002108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208267
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