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Genetic anticipation in BRCA1/2 families after controlling for ascertainment bias and cohort effect

BACKGROUND: Genetic anticipation, the earlier onset of disease in successive generations, has been reported in hereditary breast and ovarian cancer syndrome (HBOC), but little is known about its underlying mechanisms. Ascertainment bias is a reason that has been suggested in previous studies. Likewi...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cancer
Main Authors: Guindalini, Rodrigo Santa Cruz, Song, Andrew, Fackenthal, James D., Olopade, Olufunmilayo I., Huo, Dezheng
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892951/
https://ncbi.nlm.nih.gov/pubmed/26992017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29972
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