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Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model
Insulin receptor substrate-2-deficient (IRS2(−/−)) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play...
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| Publicado no: | Dis Model Mech |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4892662/ https://ncbi.nlm.nih.gov/pubmed/27013528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023515 |
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