Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

The hexosamine biosynthetic pathway (HBP) is a nutrient-sensing metabolic pathway that produces the activated amino sugar UDP-N-acetylglucosamine, a critical substrate for protein glycosylation. Despite its biological significance, little is known about the regulation of HBP flux during nutrient lim...

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Udgivet i:Sci Rep
Main Authors: Chaveroux, Cédric, Sarcinelli, Carmen, Barbet, Virginie, Belfeki, Sofiane, Barthelaix, Audrey, Ferraro-Peyret, Carole, Lebecque, Serge, Renno, Toufic, Bruhat, Alain, Fafournoux, Pierre, Manié, Serge N.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891703/
https://ncbi.nlm.nih.gov/pubmed/27255611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27278
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