Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer

BACKGROUND: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a target of Wnt signalling and considered both a cancer stem cell marker and intestinal stem cell marker. We found first some splice variants of LGR5 in human intestine and elucidated the functional feature of full-len...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Osawa, Hideki, Takahashi, Hidekazu, Nishimura, Junichi, Ohta, Katsuya, Haraguchi, Naotsugu, Hata, Taishi, Yamamoto, Hirofumi, Mizushima, Tsunekazu, Takemasa, Ichiro, Doki, Yuichiro, Mori, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891500/
https://ncbi.nlm.nih.gov/pubmed/27140312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.112
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