A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

Current tools for the inhibition of microRNA (miR) function are limited to modified antisense oligonucleotides, sponges and decoy RNA molecules and none have been used to understand miR function during development. CRISPR/Cas-mediated deletion of miR sequences within the genome requires multiple chr...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Cao, H, Yu, W, Li, X, Wang, J, Gao, S, Holton, N E, Eliason, S, Sharp, T, Amendt, B A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article - Enabling Technologies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891277/
https://ncbi.nlm.nih.gov/pubmed/26934100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.22
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