A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

CD47 is a signaling receptor for thrombospondin-1 and the counter-receptor for signal-regulatory protein-α (SIRPα). By inducing inhibitory SIRPα signaling, elevated CD47 expression by some cancers prevents macrophage phagocytosis. The anti-human CD47 antibody B6H12 inhibits tumor growth in several x...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kaur, Sukhbir, Elkahloun, Abdel G., Singh, Satya P., Chen, Qing-Rong, Meerzaman, Daoud M., Song, Timothy, Manu, Nidhi, Wu, Weiwei, Mannan, Poonam, Garfield, Susan H., Roberts, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891109/
https://ncbi.nlm.nih.gov/pubmed/26840086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7100
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