In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library.
We have used a combinatorial immunoglobulin library approach to obtain monoclonal antibodies from nonimmune adult mice, thereby establishing the principles of (i) accessing naive combinatorial antibody libraries for predetermined specificities and (ii) increasing the affinity of the selected antibod...
Spremljeno u:
| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1992
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1565653/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.8.3576 |
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