JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells

OBJECTIVE: Successful treatment of solid cancers mandates targeting cancer stem cells (CSC) without impact on the physiology of normal tissue resident stem cells. C-Jun N-terminal kinase (JNK) signaling has been shown to be of importance in cancer. We test whether JNK inhibition would sensitize panc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Recio-Boiles, Alejandro, Ilmer, Matthias, Rhea, P. Robyn, Kettlun, Claudia, Heinemann, Mitja L., Ruetering, Jennifer, Vykoukal, Jody, Alt, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891091/
https://ncbi.nlm.nih.gov/pubmed/26840266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7066
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