Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development

Methylation of CpG islands in tumor suppressor gene prompter is one of the most characteristic abnormalities in Helicobacter pylori (HP)-associated gastric carcinoma (GC). Here, we investigated the pathogenic and molecular mechanisms underlying hypermethylation of tumor suppressor genes in HP induce...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Bao-gui, Hu, Lei, Zang, Ming-de, Wang, He-xiao, Zhao, Wei, Li, Jian-fang, Su, Li-ping, Shao, Zhifeng, Zhao, Xiaodong, Zhu, Zheng-gang, Yan, Min, Liu, Bingya
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891084/
https://ncbi.nlm.nih.gov/pubmed/26848521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7125
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