Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies and has poor therapeutic options. We evaluated improved oncolytic adenoviruses (OAds), in which the adenoviral gene E1B19K was deleted or a TRAIL transgene was inserted. Bone marrow mesenchymal stromal cells (MSCs) ser...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Kaczorowski, Adam, Hammer, Katharina, Liu, Li, Villhauer, Sabine, Nwaeburu, Clifford, Fan, Pei, Zhao, Zhefu, Gladkich, Jury, Groß, Wolfgang, Nettelbeck, Dirk M., Herr, Ingrid
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891025/
https://ncbi.nlm.nih.gov/pubmed/26824985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7031
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