High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β(2)-Adrenoceptor/Gi-Dependent Manner: A New Model of Takotsubo Cardiomyopathy

BACKGROUND: Takotsubo cardiomyopathy is an acute heart failure syndrome characterized by myocardial hypocontractility from the mid left ventricle to apex. It is precipitated by extreme stress and can be triggered by intravenous catecholamine administration, particularly epinephrine. Despite its grav...

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Pubblicato in:Circulation
Autori principali: Paur, Helen, Wright, Peter T., Sikkel, Markus B., Tranter, Matthew H., Mansfield, Catherine, O'Gara, Peter, Stuckey, Daniel J., Nikolaev, Viacheslav O., Diakonov, Ivan, Pannell, Laura, Gong, Haibin, Sun, Hong, Peters, Nicholas S., Petrou, Mario, Zheng, Zhaolun, Gorelik, Julia, Lyon, Alexander R., Harding, Sian E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890655/
https://ncbi.nlm.nih.gov/pubmed/22732314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.111591
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