High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β(2)-Adrenoceptor/Gi-Dependent Manner: A New Model of Takotsubo Cardiomyopathy

BACKGROUND: Takotsubo cardiomyopathy is an acute heart failure syndrome characterized by myocardial hypocontractility from the mid left ventricle to apex. It is precipitated by extreme stress and can be triggered by intravenous catecholamine administration, particularly epinephrine. Despite its grav...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Paur, Helen, Wright, Peter T., Sikkel, Markus B., Tranter, Matthew H., Mansfield, Catherine, O'Gara, Peter, Stuckey, Daniel J., Nikolaev, Viacheslav O., Diakonov, Ivan, Pannell, Laura, Gong, Haibin, Sun, Hong, Peters, Nicholas S., Petrou, Mario, Zheng, Zhaolun, Gorelik, Julia, Lyon, Alexander R., Harding, Sian E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890655/
https://ncbi.nlm.nih.gov/pubmed/22732314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.111591
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