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The role of context in RNA structure: flanking sequences reconfigure CAG motif folding in huntingtin exon 1 transcripts

The length of the CAG repeat region in the huntingtin messenger RNA is predictive of Huntington’s disease. Structural studies of CAG repeat-containing RNAs suggest that these sequences form simple hairpin structures; however, in the context of the full-length huntingtin mRNA, CAG repeats may form co...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Busan, Steven, Weeks, Kevin M.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890576/
https://ncbi.nlm.nih.gov/pubmed/24199621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401129r
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