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The role of context in RNA structure: flanking sequences reconfigure CAG motif folding in huntingtin exon 1 transcripts
The length of the CAG repeat region in the huntingtin messenger RNA is predictive of Huntington’s disease. Structural studies of CAG repeat-containing RNAs suggest that these sequences form simple hairpin structures; however, in the context of the full-length huntingtin mRNA, CAG repeats may form co...
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| Publicado en: | Biochemistry |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4890576/ https://ncbi.nlm.nih.gov/pubmed/24199621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401129r |
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