CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking

α7 nicotinic acetylcholine receptor (α7nAChR, encoded by CHRNA7) is involved in dementia pathogenesis through cholinergic neurotransmission, neuroprotection and interactions with amyloid-β. Smoking promotes atherosclerosis and increases dementia risk, but nicotine exerts neuroprotective effect via α...

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Pubblicato in:Sci Rep
Autori principali: Weng, Pei-Hsuan, Chen, Jen-Hau, Chen, Ta-Fu, Sun, Yu, Wen, Li-Li, Yip, Ping-Keung, Chu, Yi-Min, Chen, Yen-Ching
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890170/
https://ncbi.nlm.nih.gov/pubmed/27249957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27231
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