IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches

Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer’s patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the sup-epithelial dome (SED) of PPs....

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Gepubliceerd in:Science
Hoofdauteurs: Reboldi, Andrea, Arnon, Tal I., Rodda, Lauren B., Atakilit, Amha, Sheppard, Dean, Cyster, Jason G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890166/
https://ncbi.nlm.nih.gov/pubmed/27174992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf4822
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