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A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets
A continuing challenge in the analysis of massively large sequencing data sets is quantifying and interpreting non-neutrally evolving mutations. Here, we describe a flexible and robust approach based on the site frequency spectrum to estimate the fraction of deleterious and adaptive variants from la...
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| Veröffentlicht in: | Genome Res |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889975/ https://ncbi.nlm.nih.gov/pubmed/27197222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.203059.115 |
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