High-density array of well-ordered HIV-1 spikes on synthetic liposomal nanoparticles efficiently activate B cells

A major step towards an HIV-1 vaccine is an immunogen capable of inducing neutralizing antibodies. Envelope glycoprotein (Env). mimetics, such as the NFL and SOSIP designs, generate native-like, well-ordered trimers and elicit tier 2 homologous neutralization (SOSIPs). We reasoned that the display o...

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Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Ingale, Jidnyasa, Stano, Armando, Guenaga, Javier, Sharma, Shailendra Kumar, Nemazee, David, Zwick, Michael B, Wyatt, Richard T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889521/
https://ncbi.nlm.nih.gov/pubmed/27210756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.078
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