The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase

N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural tetrapeptide with anti-inflammatory and antifibrotic properties. Previously, we have shown that prolyl oligopeptidase (POP) is involved in the Ac-SDKP release from thymosin-β4 (Tβ4). However, POP can only hydrolyze peptides shorter than 30...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Kumar, Nitin, Nakagawa, Pablo, Janic, Branislava, Romero, Cesar A., Worou, Morel E., Monu, Sumit R., Peterson, Edward L., Shaw, Jiajiu, Valeriote, Frederick, Ongeri, Elimelda M., Niyitegeka, Jean-Marie V., Rhaleb, Nour-Eddine, Carretero, Oscar A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889319/
https://ncbi.nlm.nih.gov/pubmed/26962108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00562.2015
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