Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

Class I antigens encoded in the major histocompatibility complex (MHC) (HLA in man, H-2 in the mouse) play a key role in the recognition of target cells by cytolytic T lymphocytes. Tumor cells frequently do not express class I MHC molecules, which strongly suggests that down-regulation of the latter...

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Autors principals: Blanchet, O, Bourge, J F, Zinszner, H, Israel, A, Kourilsky, P, Dausset, J, Degos, L, Paul, P
Format: Artigo
Idioma:Inglês
Publicat: 1992
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC48893/
https://ncbi.nlm.nih.gov/pubmed/1565643
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