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Acrolein-mediated conduction loss is partially restored by K(+) channel blockers

Acrolein-mediated myelin damage is thought to be a critical mechanism leading to conduction failure following neurotrauma and neurodegenerative diseases. The exposure and activation of juxtaparanodal voltage-gated K(+) channels due to myelin damage leads to conduction block, and K(+) channel blocker...

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Bibliografiska uppgifter
I publikationen:J Neurophysiol
Huvudupphovsmän: Yan, Rui, Page, Jessica C., Shi, Riyi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888969/
https://ncbi.nlm.nih.gov/pubmed/26581866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00467.2015
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