The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas

BACKGROUND: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). Because they yield the same oncometabolite, D-2-hydroxyglutarate, they are often treated as equivalent and pooled. The objective of t...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Wang, Hao-Yuan, Tang, Kai, Liang, Ting-Yu, Zhang, Wei-Zhong, Li, Ji-Ye, Wang, Wen, Hu, Hui-Min, Li, Ming-Yang, Wang, Hui-Qing, He, Xiao-Zheng, Zhu, Zhi-Yuan, Liu, Yan-Wei, Zhang, Shi-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888668/
https://ncbi.nlm.nih.gov/pubmed/27245697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0362-7
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