Endolysosomal two‐pore channels regulate autophagy in cardiomyocytes

KEY POINTS: Two‐pore channels (TPCs) were identified as a novel family of endolysosome‐targeted calcium release channels gated by nicotinic acid adenine dinucleotide phosphate, as also as intracellular Na(+) channels able to control endolysosomal fusion, a key process in autophagic flux. Autophagy,...

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Bibliographic Details
Published in:J Physiol
Main Authors: García‐Rúa, Vanessa, Feijóo‐Bandín, Sandra, Rodríguez‐Penas, Diego, Mosquera‐Leal, Ana, Abu‐Assi, Emad, Beiras, Andrés, María Seoane, Luisa, Lear, Pamela, Parrington, John, Portolés, Manuel, Roselló‐Lletí, Esther, Rivera, Miguel, Gualillo, Oreste, Parra, Valentina, Hill, Joseph A., Rothermel, Beverly, González‐Juanatey, José Ramón, Lago, Francisca
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887684/
https://ncbi.nlm.nih.gov/pubmed/26757341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271332
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