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Pharmacological modulation of lateral habenular dopamine D2 receptors alters the anxiogenic response to cocaine in a runway model of drug self-administration

Cocaine has long been known to produce an initial “high” followed by an aversive/anxiogenic “crash”. While much is known about the neurobiology of cocaine’s positive/rewarding effects, the mechanisms that give rise to the drug’s negative/anxiogenic actions remain unclear. Recent research has implica...

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Pubblicato in:Behav Brain Res
Autori principali: Shelton, Kerisa, Bogyo, Kelsie, Schick, Tinisha, Ettenberg, Aaron
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887427/
https://ncbi.nlm.nih.gov/pubmed/27155504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2016.05.002
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