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Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism

BACKGROUND: Isolated nonsyndromic clubfoot is a common birth defect affecting 135,000 newborns worldwide each year. Although treatment has improved, substantial long-term morbidity persists. Genetic causes have been implicated in family-based studies but the genetic changes have eluded identificatio...

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Publicat a:Clin Orthop Relat Res
Autors principals: Weymouth, Katelyn S., Blanton, Susan H., Powell, Tamar, Patel, Chandrashekhar V., Savill, Stuart A., Hecht, Jacqueline T.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887369/
https://ncbi.nlm.nih.gov/pubmed/27020427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11999-016-4788-1
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