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Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism

The quantal nature of synaptic transmission requires a mechanism to transport neurotransmitter into synaptic vesicles without promoting non-vesicular efflux across the plasma membrane. Indeed, the vesicular transport of most classical transmitters involves a mechanism of H(+) exchange which restrict...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Eriksen, Jacob, Chang, Roger, McGregor, Matt, Silm, Katlin, Suzuki, Toshiharu, Edwards, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886649/
https://ncbi.nlm.nih.gov/pubmed/27133463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.03.026
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