mTOR inhibitors effects on regulatory T cells and on dendritic cells

The mammalian target of rapamycin (mTOR), a cytoplasmic serine/threonine kinase, represents a key biologic “switch” modulating cell metabolisms in response to environmental signals and is now recognized as a central regulator of the immune system. There is an increasing body of evidence supporting t...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Stallone, Giovanni, Infante, Barbara, Di Lorenzo, Adelaide, Rascio, Federica, Zaza, Gianluigi, Grandaliano, Giuseppe
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886438/
https://ncbi.nlm.nih.gov/pubmed/27245075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0916-7
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